How Can a Polymeric Formula Induce Remission in Crohn’s Disease Patients?

International Journal of Molecular Sciences

卷:22

Emmanuel Mas¹  Frederick Barreau¹  Kawthar Boumessid¹ 

[1] INSERM, INRAE, ENVT, Université de Toulouse, UPS, F-31000 Toulouse, France;

关键词: Crohn’s disease;    inflammatory bowel disease;    exclusive enteral nutrition;    mucosal healing;   

DOI  :  10.3390/ijms22084025

来源: DOAJ

【 摘 要 】

Crohn’s disease is an inflammatory bowel disease whose prevalence is increasing worldwide. Among medical strategies, dietary therapy with exclusive enteral nutrition is recommended as a first-line option, at least for children, because it induces clinical remission and mucosal healing. Modulen^®, a polymeric TGF-β2 enriched formula, has good palatability and is widely used. For the first time in the literature, this review outlines and discusses the clinical outcomes obtained with this therapy, as well as the potential mechanisms of action of its compounds. It can be explained by its TGF-β2 content, but also by its protein and lipid composition. Further well-designed studies are required to improve our knowledge and to optimize therapeutic strategies.

【 授权许可】

Unknown