CYTOKINE-PRODUCING FUNCTION OF PERIPHERAL BLOOD CELLS IN COLORECTAL CANCER PATIENTS

Medicinskaâ Immunologiâ

卷:13

N. V. Velikaya¹  N. A. Varaksin²  M. Yu. Rukhavishnikov²  A. V. Sosnina³  A. I. Autenshlyus³  D. V. Morozov³  E. S. Mikhailova³  S. A. Fursov⁴  N. V. Agarina⁴ 

[1] ;

[2] ЗАО «Вектор-Бест», г. Новосибирск;

[3] НИИ молекулярной биологии и биофизики СО РАМН, г. Новосибирск;

[4] Новосибирский областной онкологический диспансер, г. Новосибирск;

关键词: cytokines;    polyclonal activators;    colorectal cancera;   

DOI  :  10.15789/1563-0625-2011-2-3-197-204

来源: DOAJ

【 摘 要 】

Аbstract. The aim of present study was to investigate an influence of polyclonal activators upon cytokine-producing function of peripheral blood cells in the patients with colorectal adenocarcinomas. It was revealed that the stimulated production of IL-1β, IL-1ra, IL-2, IL-17, IL-18 and IFNγ by whole blood cells treated with polyclonal activators was significantly decreased in colorectal cancer patients, as compared to healthy individuals. The stimulated IL-1ra and IL-17 production was depressed during the tumor progression, along with increased release of TNFα and IL-8. It was found that the stimulation index of polyclonal activators upon production of IL-17 by whole blood cells (i.e., a cytokine production ratio of stimulated versus resting cells) may be used as a reliable pre-surgery predictor of tumor invasion, the latter being an important histopathological parameter for clinical oncologists. (Med. Immunol., 2011, vol. 13, N 2-3, pp 197-204

【 授权许可】

Unknown