Comparison of Characteristics of Neuropathic and Non-neuropathic Pruritus to Develop a Tool for the Diagnosis of Neuropathic Pruritus: The NP5

Frontiers in Medicine

卷:6

Johanna Huguen¹  Caroline-Jade Clerc²  Gaëlle Quereux³  Laurent Misery⁵  Pascale Marcorelles⁵  Emilie Brenaut⁶  Florence Poizeau⁷  Alain Dupuy⁷ 

[1] Department of Dermatology, Quimper Hospital, Quimper, France;

[2] Department of Dermatology, University Hospital, Brest, France;

[3] Department of Dermatology, University Hospital, Nantes, France;

[4] Department of Dermatology, University Hospital, Rennes, France;

[5] Department of Pathology, University Hospital, Brest, France;

[6] Laboratoire Interactions Epitheliums Neurones, Université de Bretagne Occidentale, Brest, France;

[7] UPRES EA 7449 REPERES Pharmacoepidemiology and Health Services Research, Rennes University, Rennes, France;

关键词: neuropathic;    pruritus;    small fiber neuropathies;    questionnaire;    diagnosis;   

DOI  :  10.3389/fmed.2019.00079

来源: DOAJ

【 摘 要 】

The diagnosis of neuropathic pruritus (NP) may be difficult. The aim of this study was to compare the characteristics of both neuropathic pruritus and non-neuropathic pruritus (NNP) in order to elaborate a tool to help the diagnosis of NP without clinical examination. One hundred and seven patients were included: Fifty three in the NP group and Fifty four in the NNP group. In multiple regression, presence of twinges, absence of burning, worsening with activity, no worsening with stress, and relief with cold ambient temperature were independent factors that were associated with NP. A score of two criteria out of five was optimal to discriminate NP from NNP with a sensitivity of 76% and a specificity of 77%. Alloknesis, hyperknesis, or the ice cube test were not included because their evaluation is based on clinical examination. Future high-powered studies are needed to confirm the results of the present study.

【 授权许可】

Unknown