Comparison of Characteristics of Neuropathic and Non-neuropathic Pruritus to Develop a Tool for the Diagnosis of Neuropathic Pruritus: The NP5

Frontiers in Medicine

article

Johanna Huguen¹  Emilie Brenaut¹  Caroline-Jade Clerc¹  Florence Poizeau¹  Pascale Marcorelles³  Gaëlle Quereux¹  Alain Dupuy¹  Laurent Misery³ 

[1] Department of Dermatology, University Hospital;Department of Dermatology, Quimper Hospital;Laboratoire Interactions Epitheliums Neurones, Université de Bretagne Occidentale;UPRES EA 7449 REPERES Pharmacoepidemiology and Health Services Research, Rennes University;Department of Pathology, University Hospital

关键词: neuropathic;    pruritus;    small fiber neuropathies;    questionnaire;    diagnosis;   

DOI  :  10.3389/fmed.2019.00079

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

The diagnosis of neuropathic pruritus (NP) may be difficult. The aim of this study was to compare the characteristics of both neuropathic pruritus and non-neuropathic pruritus (NNP) in order to elaborate a tool to help the diagnosis of NP without clinical examination. One hundred and seven patients were included: Fifty three in the NP group and Fifty four in the NNP group. In multiple regression, presence of twinges, absence of burning, worsening with activity, no worsening with stress, and relief with cold ambient temperature were independent factors that were associated with NP. A score of two criteria out of five was optimal to discriminate NP from NNP with a sensitivity of 76% and a specificity of 77%. Alloknesis, hyperknesis, or the ice cube test were not included because their evaluation is based on clinical examination. Future high-powered studies are needed to confirm the results of the present study.

【 授权许可】

CC BY