期刊论文详细信息
International Journal of Molecular Sciences 卷:22
Toxicity and Antioxidant Activity of Fullerenol C60,70 with Low Number of Oxygen Substituents
Arina G. Kicheeva1  Nadezhda S. Kudryasheva2  Ekaterina S. Kovel2  Evsei A. Stepin3  Grigory N. Churilov4  Natalia G. Vnukova4 
[1] FRC KSC SB RAS, 660036 Krasnoyarsk, Russia;
[2] Institute of Biophysics SB RAS, FRC KSC SB RAS, 660036 Krasnoyarsk, Russia;
[3] Institute of Fundamental Biology and Biotechnology, Siberian Federal University, 660041 Krasnoyarsk, Russia;
[4] Institute of Physics SB RAS, FRC KSC SB RAS, 660036 Krasnoyarsk, Russia;
关键词: fullerenol;    toxicity;    antioxidant activity;    reactive oxygen species;    bioluminescent assay;    hormesis;   
DOI  :  10.3390/ijms22126382
来源: DOAJ
【 摘 要 】

Fullerene is a nanosized carbon structure with potential drug delivery applications. We studied the bioeffects of a water-soluble fullerene derivative, fullerenol, with 10-12 oxygen groups (F10-12); its structure was characterized by IR and XPS spectroscopy. A bioluminescent enzyme system was used to study toxic and antioxidant effects of F10-12 at the enzymatic level. Antioxidant characteristics of F10-12 were revealed in model solutions of organic and inorganic oxidizers. Low-concentration activation of bioluminescence was validated statistically in oxidizer solutions. Toxic and antioxidant characteristics of F10-12 were compared to those of homologous fullerenols with a higher number of oxygen groups:F24-28 and F40-42. No simple dependency was found between the toxic/antioxidant characteristics and the number of oxygen groups on the fullerene’s carbon cage. Lower toxicity and higher antioxidant activity of F24-28 were identified and presumptively attributed to its higher solubility. An active role of reactive oxygen species (ROS) in the bioeffects of F10-12 was demonstrated. Correlations between toxic/antioxidant characteristics of F10-12 and ROS content were evaluated. Toxic and antioxidant effects were related to the decrease in ROS content in the enzyme solutions. Our results reveal a complexity of ROS effects in the enzymatic assay system.

【 授权许可】

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