BRCA1 and Oxidative Stress

Cancers

卷:6

Hyo Jin Kang¹  Insoo Bae¹  Yong Weon Yi¹ 

[1] Department of Oncology, Lombardi Comprehensive Cancer Center,Georgetown University Medical Center, Washington, DC 20057, USA;

关键词: BRCA;    oxidative stress;    reactive oxygen species (ROS);    carcinogenesis;    detoxification;   

DOI  :  10.3390/cancers6020771

来源: DOAJ

【 摘 要 】

The breast cancer susceptibility gene 1 (BRCA1) has been well established as a tumor suppressor and functions primarily by maintaining genome integrity. Genome stability is compromised when cells are exposed to oxidative stress. Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing carcinogenesis in normal cells. Oxidative stress caused by reactive oxygen species (ROS) is implicated in carcinogenesis and is used strategically to treat human cancer. Thus, it is essential to understand the function of BRCA1 in oxidative stress regulation. In this review, we briefly summarize BRCA1’s many binding partners and mechanisms, and discuss data supporting the function of BRCA1 in oxidative stress regulation. Finally, we consider its significance in prevention and/or treatment of BRCA1-related cancers.

【 授权许可】

Unknown