Impact of Co-Culture on the Metabolism of Marine Microorganisms

Marine Drugs

卷:20

Nathalie Tapissier-Bontemps¹  Flore Caudal²  Ru Angelie Edrada-Ebel³ 

[1] CRIOBE, USR3278-EPHE/CNRS/UPVD/PSL, University of Perpignan via Domitia, 52 Avenue Paul Alduy, 66860 Perpignan, France;

[2] Laboratoire Biotechnologie et Chimie Marines, Université Bretagne Sud, EA3884, LBCM, IUEM, CEDEX, 56321 Lorient, France;

[3] The Natural Products Metabolomics Group, Strathclyde Institute of Pharmacy and Biomedical Sciences, Faculty of Science, University of Strathclyde, The John Arbuthnott Building, 161 Cathedral Street, Glasgow G4 0RE, UK;

关键词: co-culture;    natural products;    marine bacteria;    marine fungi;   

DOI  :  10.3390/md20020153

来源: DOAJ

【 摘 要 】

Natural products from plants have been listed for hundreds of years as a source of biologically active molecules. In recent years, the marine environment has demonstrated its ability to provide new structural entities. More than 70% of our planet’s surface is covered by oceans, and with the technical advances in diving and remotely operated vehicles, it is becoming easier to collect samples. Although the risk of rediscovery is significant, the discovery of silent gene clusters and innovative analytical techniques has renewed interest in natural product research. Different strategies have been proposed to activate these silent genes, including co-culture, or mixed fermentation, a cultivation-based approach. This review highlights the potential of co-culture of marine microorganisms to induce the production of new metabolites as well as to increase the yields of respective target metabolites with pharmacological potential, and moreover to indirectly improve the biological activity of a crude extract.

【 授权许可】

Unknown