Long noncoding RNAs (lncRNAs) in human lymphomas

Genes and Diseases

卷:9

Ali Gholami¹  Fatemeh Sayyadipour¹  Khosro Farhadi¹  Masoud Soleimani²  Fakhredin Saba³ 

[1] Clinical Research Development Center, Taleghani and Imam Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran;

[2] Department of Haematology, Tarbiat Modares University, Tehran 146899-5513, Iran;

[3] Department of Medical Laboratory Science, School of Paramedical, Kermanshah University of Medical Sciences, Kermanshah 671568-5420, Iran;

关键词: Apoptosis;    Long non-coding RNA;    Lymphoma;    Prognosis;    Proliferation;   

DOI  :  

来源: DOAJ

【 摘 要 】

Lymphomas are a diverse group of haematologic malignancies, which occur in infection-fighting cells of the lymphatic system. Long non-coding RNAs (lncRNAs) are non-coding RNAs, which have recently received significant attention as the main mediators of gene expression. In this review, we summarize the current knowledge on lncRNAs involved in lymphomas, their molecular functions, as well as their potential clinical value. Relevant literature was identified by a PubMed search of English language papers using the following terms: Lymphoma, LncRNA, leukemia, proliferation, apoptosis, and prognosis. LncRNAs are imperative for lymphoma carcinogenesis through affecting apoptosis, cell proliferation, invasion, and response to chemotherapy. The expression level of lncRNAs can affect chemotherapy-induced apoptosis. Taken together, lncRNA dysregulation in lymphoma cells is not only an epiphenomenon but also lncRNA transcription is critically related to the initiation and progression of lymphomas. Aberrant expression of lncRNAs can lead to the transformation of normal lymphocytes into lymphoma cells.

【 授权许可】

Unknown