PRELIMINARY STRUCTURE–ACTIVITY RELATIONSHIP STUDY OF HEPTAMETHINE INDOCYANINE DYES FOR TUMOR-TARGETED IMAGING

Journal of Innovative Optical Health Sciences

卷:6

QINGRONG QI¹  SHENGLIN LUO²  CHUNMENG SHI²  QINYUAN GUO² 

[1] Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, P. R. China;

[2] Institute of Combined Injury State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering, Research Center for Nanomedicine, College of Preventive, Medicine, Third Military Medical University, Chongqing 400038, P. R. China;

关键词: Heptamethine indocyanine dyes;    NIR imaging;    tumor targeting;    SAR study;   

DOI  :  10.1142/S179354581350003X

来源: DOAJ

【 摘 要 】

Our research has identified a couple of near-infrared (NIR) heptamethine indocyanine dyes exhibiting preferential tumor accumulation property for in vivo imaging. On the basis of our foregoing work, we describe here a preliminary structure–activity relationship (SAR) study of 11 related heptamethine indocyanine dyes and several essential requirements of these structures for in vivo tumor-targeted imaging.

【 授权许可】

Unknown