N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

Molecules

Jian Wu¹  Shenghong Kang²  Qinkun Yuan²  Lijun Luo²  Juan Ma²  Qingcai Shi² 

[1] State Key Laboratory Breeding Base of Green Pesticides and Agricultural Bioengineering, Key Laboratory of Green Pesticides and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China;

关键词: pridazin-3(2H)-one;    synthesis;    insecticidal activity;    SAR study;    Plutella xylostella;   

DOI  :  10.3390/molecules17089413

来源: mdpi

【 摘 要 】

A series of N-substituted 5–chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed >90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.