N-Substituted 5-Chloro-6-phenylpyridazin-3(2H)-ones: Synthesis, Insecticidal Activity Against Plutella xylostella (L.) and SAR Study

Molecules

卷:17

关键词: pridazin-3(2<;    em>;    H<;    /em>;    )-one;    synthesis;    insecticidal activity;    SAR study;    <;    em>;    Plutella <;    /em>;    <;    em>;    xylostella<;    /em>;   

DOI  :  10.3390/molecules17089413

来源: DOAJ

【 摘 要 】

A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.

【 授权许可】

Unknown