An Increase Incidence in Uric Acid Nephrolithiasis: Changing Patterns

Journal of Clinical and Diagnostic Research

卷:10

Piyush Bansal¹  Sumit Dokwal²  Asha Kumari³  Jaikrit Bhutani⁴  Rajender Kumar⁵  Richa Goel⁵  Himanshu Devender Kumar⁵  Pawan Mittal⁶ 

[1] Assistant Professor, Department of Biochemistry, BPS GMC, Khanpur, Sonepat, Haryana, India. ;

[2] Assistant Professor, Department of Biochemistry, PGIMS, Rohtak, Haryana, India. ;

[3] Demonstrator, Department of Biochemistry, PGIMS, Rohtak, Haryana, India.;

[4] House Surgeon, Department of Pulmonary and Critical Care Medicine, PGIMS, Rohtak, Haryana, India.;

[5] Junior Resident, Department of Biochemistry, PGIMS, Rohtak, Haryana, India.;

[6] Medical Officer, ESI, Pinjore, Haryana, India.;

关键词: renal stones;    stone composition;    pcnl;    oxalate;    paradigm shift in renal stones;   

DOI  :  10.7860/JCDR/2016/19714.8139

来源: DOAJ

【 摘 要 】

Introduction: Nephrolithiasis is a complex disease affecting allage groups globally. As the causative factors for nephrolithiasisrises significantly, its incidence, prevalence and recurrencecontinues to baffle clinicians and patients.Aim: To study the prevalence of different types of renal stonesextracted by Percutaneous Nephrolithotomy (PCNL) and opensurgical procedures.Materials and Methods: Renal stones from 50 patientswere retrieved by Percutaneous Nephrolithotomy (PCNL),Ureterorenoscopy (URS) and open surgical techniques forqualitative tests for detection of calcium, oxalate, uric acid,phosphate, ammonium ion, carbonate, cystine and xanthine.Results: Three patients had stone removed by open surgeryand rest had undergone PCNL. Nine of the stones were pureof calcium oxalate, 9 were of pure uric acid and 32 were mixedstones. Forty one stones had calcium. Among the mixed stones,oxalate was present in 25 samples (39 of total), uric acid wasseen in 17 (25 of total stones), phosphate was present in 23(23 of total) and carbonate was present in 4 stones (4 of total).Only 1 patient had triple phosphate stone. 12 were of staghornappearance of which 6 were of struvite type, 6 were pure uricacid and remaining were mixed oxalate-phosphate stones.Conclusion: Our study, though in a small number of hospitalbased patients, found much higher prevalence of uric acidstones and mixed stones than reported by previous hospitalbased studies in north India (oxalate stones~90%, uric acid~1%and mixed stones~3%). Biochemical analysis of renal stones iswarranted in all cases.

【 授权许可】

Unknown