The influence of prenatal exposure to trans-fatty acids for development of childhood haematopoietic neoplasms (EnTrance): a natural societal experiment and a case-control study

Nutrition Journal

卷:17

Eva Steliarova-Foucher¹  Veronique Chajes²  Inge Huybrechts²  Peder Frederiksen³  Ina Olmer Specht³  Berit Lilienthal Heitmann³ 

[1] International Agency for Research on Cancer (IARC), Cancer Surveillance Section (CSU);

[2] International Agency for Research on Cancer (IARC), Nutrition and Metabolism Section;

[3] Parker Institute, Research Unit for Dietary Studies, Frederiksberg and Bispebjerg Hospital;

关键词: Trans fatty acids;    Childhood leukemia;    Childhood cancer;    In utero;    Prenatal;    Haematopoietic neoplasms;   

DOI  :  10.1186/s12937-018-0317-2

来源: DOAJ

【 摘 要 】

Abstract Background Little is known about the causes of childhood cancer, partly as not many children develop cancer, although childhood cancer is a leading cause of death by disease in the young. The young age of the children suggests that risk factors for childhood cancer may be present during pregnancy. Previous studies have shown that exposure to trans-fat, a type of unsaturated fat common in industrially produced foods (iTFA), has adverse health effects in adults, including the risk of developing cancer. Haematopoietic neoplasms are the most common cancer types among European children under the age of 15 years. This study will bring new knowledge as to whether trans-fat and other fatty acids may also increase the risk of developing haematopoietic neoplasms during childhood. Methods We will investigate if the Danish iTFA legislation ban, which radically reduced the use of iTFA in foodstuffs, influenced the risk of childhood haematopoietic neoplasms in children born either before or after the change in legislation, adjusting for relevant secular trends. Further, in a case-control study, we will examine if levels of fatty acids in dried blood spots from newborns can predict the risk of developing childhood haematopoietic neoplasms. Permission from the Danish Data Protection Agency and the Ethical Committee has been granted. Discussion The results from this study will provide important information about fatty acids in the mother’s diet as a contributor to development of haematopoietic neoplasms during childhood, which may result in relevant preventive action. Trial registration Not relevant.

【 授权许可】

Unknown