Moxibustion for cognitive impairment: A systematic review and meta-analysis of animal studies

Integrative Medicine Research

卷:10

Jun-Hwan Lee¹  Mudan Cai²  Ui Min Jerng³  Seon Choe⁴  Sungmin Aum⁵ 

[1] Corresponding authors at: Department of Internal Medicine, College of Korean Medicine, Sangji University, Wonju 26339, Republic of Korea (U.M. Jerng);

[2] Clinical Medicine Division, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea;

[3] Department of Internal Medicine, College of Korean Medicine, Sangji University, Wonju, Republic of Korea;

[4] Seoul National University Biomedical Informatics (SNUBI), Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul, Republic of Korea;

[5] University of Science and Technology (UST), Daejeon, Republic of Korea;

关键词: Animal experimentation;    Cognitive impairment;    Dementia;    Moxibustion;    Systematic review;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Cognitive impairment is an age-dependent chronic disorder that exponentially worsens with age; however, its treatment is mostly symptomatic. Moxibustion is widely accepted in East Asia as a treatment for cognitive impairment. This systematic review aimed to verify the efficacy and underlying mechanism of moxibustion in treating cognitive impairment. Methods: Sixteen trials involving 324 animals obtained from MEDLINE (PubMed), EMBASE, the Cochrane library, the Chinese National Knowledge Infrastructure, Wan-Fang, Cqvip, the Korean Studies Information Service System, and the Oriental Medicine Advanced Searching Integrated System met the inclusion criteria. We extracted the results of behavioral tests and immunohistochemical biomarkers from the included articles and evaluated the risk of bias and reporting quality. Results: The moxibustion group showed significantly decreased escape latency, increased crossing times, and prolonged dwelling times in the Morris water maze test. There was a significantly enhanced latency period and reduced error time in the step-down test and nerve behavior score. The effects of moxibustion were found to be mediated by suppression of oxidative stress and apoptosis, modulation of inflammation and Aβ genesis activation of vascular endothelial growth factor, and adjustment of metabolites in the tricarboxylic acid cycle and fatty acid metabolism. Conclusion: Our results demonstrated the therapeutic efficacy of moxibustion on cognitive impairment and suggested the putative mechanism. However, considering the small number of included studies, high bias risk, low reporting quality, and the limitations of animal experimentation, our results need to be confirmed by more detailed studies.

【 授权许可】

Unknown