Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma

BMC Cancer

卷:18

Dan Zhang¹  Manni Wang¹  Jinggan Wang¹  Xuelei Ma¹  Hao Zeng¹  Linyan Chen¹  Sha Zhu¹  Jiapeng Yang¹  Yuqing Lu²  Chienyun Kuang³ 

[1] Department of Biotherapy, Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center;

[2] The People’s Hospital of Hechi;

[3] West China School of Stomatology, Sichuan University;

关键词: Laryngeal cancer;    Neutrophil;    Lymphocyte;    Platelet;    Monocyte;    Prognosis;   

DOI  :  10.1186/s12885-018-4730-x

来源: DOAJ

【 摘 要 】

Abstract Background To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC). Methods A total of 361 resected LSCC patients were included. The preoperative and postoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), alkaline phosphatase (ALP) and l actate dehydrogenase (LDH) were assessed. The Kaplan-Meier survival analysis and Cox regression analysis were conducted on overall survival (OS) and progression-free survival (PFS). Results Both Kaplan-Meier analysis and univariate analysis demonstrated significant prognostic value of preoperative and postoperative NLR, PLR and MLR. However, only preoperative ALP was predictive of OS and PFS, and LDH failed to be predictor of OS and PFS. The multivariate analysis showed that preoperative NLR (OS: HR = 1.64, 95%CI: 1.06–2.54, p = 0.026; PFS: HR = 1.52, 95%CI: 1.04–2.23, p = 0.029) and postoperative MLR (OS: HR = 2.02, 95%CI: 1.29–3.14, p = 0.002; PFS: HR = 1.57, 95%CI: 1.05–2.34, p = 0.026) were independently related with survival. Conclusions The elevated preoperative NLR, PLR, MLR and ALP were significantly associated with worse survival and cancer progression. The preoperative NLR and postoperative MLR might be independent prognostic markers of OS and PFS in LSCC patients undergoing surgical resection.

【 授权许可】

Unknown