Development of a Love-Wave Biosensor Based on an Analytical Model

Chemosensors

卷:10

Pedro Alberto Segura Chavez¹  Omar Elmazria¹  Jeremy Bonhomme¹  Frédéric Sarry¹  Denis Beyssen¹  Mourad Oudich¹  Mohd Khairuddin Md Arshad²  Paul G. Charette³ 

[1] Institut Jean Lamour, UMR CNRS 7198, Université de Lorraine, F-54000 Nancy, France;

[2] Institute of Nano Electronic Engineering, Universiti Malaysia Perlis, Kangar 01000, Malaysia;

[3] Laboratoire Nanotechnologies Nanosystèmes (LN2)-CNRS IRL-3463, Université de Sherbrooke, Sherbrooke, QC J1K OA5, Canada;

关键词: Love wave;    biosensor;    viscosity;    analytical model;    acoustic ratio;    ZnO;   

DOI  :  10.3390/chemosensors10020081

来源: DOAJ

【 摘 要 】

The present work deals with the development of a Love-wave biosensor for the diagnosis of the modification of cell viscosity. The relevant device performance such as insertion loss, attenuation, phase velocity, and sensitivity needs to be analysed as a function of the device structure and also regarding the effect of the liquid loading. In this study, we used an analytical model based on the equation of motions for a Love wave propagating in a three-layer structure. We show that the effect of the viscous coupling leads to insertion losses and a phase shift that impact the acoustic ratio. A comparison between experimental and theoretical results showed a good agreement between the behaviours as it was observed for the phase shift vs. the insertion loss with a limited difference in values (3.11/3.09—experimental/simulation for the sensitivity to the viscosity for different insertion losses) due to the assumptions made on the model used.

【 授权许可】

Unknown