Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

Frontiers in Immunology

卷:12

Gerald Antoch¹  Johannes Georg Bode²  Verena Keitel²  Björn Jensen²  Alexander Killer²  Tom Luedde²  Anselm Kunstein²  Caroline Klindt²  Torsten Feldt²  Annemarie Mohring³  Saskia Elben⁴  Philipp Albrecht⁴  Sven Meuth⁴  Jennifer Neubert⁵  Edwin Bölke⁶  Johannes C. Fischer⁷  Nadine Lübke⁸  Tina Senff⁸  Andreas Walker⁸  Maximilian Damagnez⁸  Heiner Schaal⁸  Lisa Müller⁸  Ortwin Adams⁸  Jörg Timm⁸  Philipp Ostermann⁸  Manfred Hoenig⁹  Ansgar S. Schulz⁹ 

[1] Department of Diagnostic and Interventional Radiology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany;

[2] Department of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany;

[3] Department of Hematology, Oncology and Clinical Immunology, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany;

[4] Department of Neurology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany;

[5] Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children’s Hospital, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany;

[6] Department of Radiation Oncology, University Hospital Duesseldorf, Medical Faculty Heinrich-Heine-University, Duesseldorf, Germany;

[7] Institute for Transplant Diagnostics and Cell Therapeutics, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University, Duesseldorf, Germany;

[8] Institute of Virology, University Hospital Duesseldorf, Medical Faculty, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany;

[9] Pediatric Stem Cell Transplantation Unit, University Hospital Ulm, Ulm, Germany;

关键词: SARS-CoV-2;    severe combined immunodeficiency;    humoral immune response;    convalescent plasma;    remdesivir;   

DOI  :  10.3389/fimmu.2021.645989

来源: DOAJ

【 摘 要 】

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.

【 授权许可】

Unknown