Increased Levels of Txa2 Induced by Dengue Virus Infection in IgM Positive Individuals Is Related to the Mild Symptoms of Dengue

Viruses

卷:10

Izabella C. A. Batista¹  Jorge G. G. Ferreira¹  Érica A. R. Alves¹  Daniele L. R. Alvarenga¹  Stella G. Colombarolli¹  Rafael R. Assis¹  Carlos E. Calzavara-Silva¹  Eneida S. Oliveira¹  Camila S. Nascimento¹  Marcele N. Rocha²  Laís O. B. de Sousa³ 

[1] Imunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, Brazil;

[2] Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Instituto René Rachou, Belo Horizonte 30190-002, Brazil;

[3] Santa Casa de Misericórdia de Santo Antônio do Monte, Santo Antônio do Monte 35560-000, Brazil;

关键词: Dengue virus;    eicosanoids;    cyclooxygenase-2;    5-lipoxygenase;    lipid bodies;   

DOI  :  10.3390/v10030104

来源: DOAJ

【 摘 要 】

The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the Dengue virus-induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during Dengue virus infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. Dengue virus infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage.

【 授权许可】

Unknown