Non-Human Primate Models of Dengue Virus Infection: A Comparison of Viremia Levels and Antibody Responses during Primary and Secondary Infection among Old World and New World Monkeys

Pathogens

卷:9

Meng Ling Moi¹  Tomohiko Takasaki²  Ichiro Kurane³  Nor AzilaMuhammad Azami⁴ 

[1] Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan;

[2] Kanagawa Prefectural Institute of Public Health, Kanagawa 253-0087, Japan;

[3] National Institute of Infectious Diseases, Tokyo 162-8640, Japan;

[4] UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia;

关键词: common marmoset;    tamarin;    cynomolgus macaque;    dengue virus;    secondary infection;    non-human primate;   

DOI  :  10.3390/pathogens9040247

来源: DOAJ

【 摘 要 】

Due to the global burden of dengue disease, a vaccine is urgently needed. One of the key points in vaccine development is the development of a robust and reliable animal model of dengue virus infection. Characteristics including the ability to sustain viral replication, demonstration of clinical signs, and immune response that resemble those of human dengue virus infection are vital in animal models. Preclinical studies in vaccine development usually include parameters such as safety evaluation, induction of viremia and antigenemia, immunogenicity, and vaccine effectiveness. Although mice have been used as a model, non-human primates have an advantage over mice because of their relative similarity to humans in their genetic composition and immune responses. This review compares the viremia kinetics and antibody responses of cynomolgus macaques (Macaca fasicularis), common marmosets (Callithrix jacchus), and tamarins (Saguinus midas and Saguinus labitus) and summarize the perspectives and the usefulness along with challenges in dengue vaccine development.

【 授权许可】

Unknown