Usefulness of random-start progestin-primed ovarian stimulation for fertility preservation

Journal of Ovarian Research

Shunichiro Ichinose¹  Shigetaka Matsunaga¹  Yukiko Itaya¹  Kouki Samejima¹  Masahiro Saitoh¹  Yasushi Takai¹  Tatsuya Narita¹  Haipeng Huang¹ 

[1] Department of Obstetrics and Gynecology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, 350-3550, Saitama, Japan;

关键词: Breast cancer;    Dydrogesterone;    Fertility preservation;    Letrozole;    Ovarian stimulation;   

DOI  :  10.1186/s13048-021-00935-5

来源: Springer

【 摘 要 】

BackgroundProgestin-primed ovarian stimulation (PPOS) has been used in infertility cases in recent years, and several reports have stated that it has oocyte collection results similar to those of gonadotropin-releasing hormone antagonist (GnRH-ant) protocol. For emergency fertility preservation, random-start ovarian stimulation is usually recommended. Therefore we compared the clinical outcomes of random-start PPOS with those of conventional random-start GnRH-ant protocols in fertility-preserving cases.MethodsWe retrospectively examined 86 cycles of oocyte collection, of which 56 were random-start GnRH-ant and 30 were random-start PPOS for fertility preservation at our hospital between January 2016 and April 2021. The primary outcome was the number of mature oocytes per cycle. The secondary outcome was the number of vitrified blastocysts per cycle for embryo freezing cases.ResultsNo significant differences were noted in the number of days of stimulation, total dose of gonadotropin preparation, and the number of mature oocytes and vitrified blastocysts. The number of hospital visits for monitoring was significantly lower in the PPOS group. The start of menstruation before oocyte collection was significantly less in the PPOS group.ConclusionsRandom-start PPOS and GnRH-ant were similar in oocyte collection results. PPOS can reduce the number of hospital visits, thus reducing patient stress. PPOS at the start of the luteal phase can prevent the start of menstruation during ovarian stimulation.

【 授权许可】

CC BY