Elevated levels of interleukin-12/23p40 may serve as a potential indicator of dysfunctional heart rate variability in type 2 diabetes

Cardiovascular Diabetology

S. Riahi¹  T. Okdahl²  C. Brock³  A. M. Wegeberg⁴  J. Størling⁵  B. Brock⁵  F. Pociot⁵  N. Ejskjaer⁶ 

[1] Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark;Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute, Aalborg University, Aalborg, Denmark;Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute, Aalborg University, Aalborg, Denmark;Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark;Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital and Clinical Institute, Aalborg University, Aalborg, Denmark;Thisted Research Unit, Aalborg University Hospital Thisted, Thisted, Denmark;Steno Diabetes Center Copenhagen, Gentofte, Denmark;Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark;Department of Endocrinology, Aalborg University Hospital, Aalborg, Denmark;

关键词: Diabetes mellitus, type 2;    Cardiovascular diseases;    Inflammation;   

DOI  :  10.1186/s12933-021-01437-w

来源: Springer

【 摘 要 】

BackgroundSystemic inflammatory processes plausibly contribute to the development of cardiovascular complications, causing increased morbidity and mortality in type 2 diabetes. Circulating inflammatory markers, i.e., interleukin (IL)-6 and tumour necrosis factor-α, are associated with neurocardiac measures. We examined a broad panel of various inflammatory and inflammation-related serum markers to obtain more detailed insight into the possible neuro-immune interaction between cardiovascular regulation and systemic level of inflammation.MethodsSerum samples from 100 participants with type 2 diabetes were analysed. Heart rate variability, cardiovascular autonomic reflex tests, and cardiac vagal tone tests were performed based on electrocardiographic readings. Data regarding covariates (demographic-, diabetes-, and cardiovascular risk factors) were registered.ResultsIncreased serum levels of IL-12/IL-23p40 (p  < 0.01) and intercellular adhesion molecule (ICAM)-1 (p  < 0.007) were associated with diminished heart rate variability measures. After all adjustments, the associations between IL-12/23p40, SDANN and VLF persisted (p  = 0.001). Additionally, serum levels of vascular endothelial growth factor (VEGF)-C were associated with response to standing (p  = 0.005).DiscussionThe few but robust associations between neurocardiac regulation and serum markers found in this study suggest systemic changes in proinflammatory, endothelial, and lymphatic function, which collectively impacts the systemic cardiovascular function. Our results warrant further exploration of IL-12/IL-23p40, ICAM-1, and VEGF-C as possible cardiovascular biomarkers in T2D that may support future decisions regarding treatment strategies for improved patient care.

【 授权许可】

CC BY