Lymph node metastasis of papillary thyroid carcinoma in the context of Hashimoto’s thyroiditis

BMC Endocrine Disorders

Jiawen Chen¹  Qi Zhou²  Juan Wang²  Min Liu²  Xin Yuan²  Lei Sun²  Lirong Wang²  Jue Jiang²  Lin Zhang² 

[1] Department of Otolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, 710004, Xi’an, China;Department of Ultrasound, the Second Affiliated Hospital of Xi’an Jiaotong University, 710004, Xi’an, China;

关键词: Hashimoto’s thyroiditis;    Papillary thyroid carcinoma;    Lymph node metastasis;    Predictive model;   

DOI  :  10.1186/s12902-021-00923-2

来源: Springer

【 摘 要 】

BackgroundWhether Hashimoto’s thyroiditis (HT) affects the lymph node metastasis of papillary thyroid carcinoma (PTC) remains uncertain. The diagnostic criteria for HT differed in previous studies. Our study focused on analysing the influence of HT on PTC lymph node metastasis (LNM) with stringent diagnostic criteria for HT.MethodsA total of 444 patients diagnosed with PTC from 2019 to 2020 were enrolled and divided into two groups: HT group and non-HT group. Diagnostic criteria of HT were as follows: thyroid peroxidase antibody (+) and postoperative histopathology of Hashimoto’s disease.ResultsThere was no significant difference in the LNM rate between HT group and non-HT group. Patients in the HT group had fewer numbers of metastatic LNs and lower metastatic LNs ratio in central region. In the HT group, age < 55 and tumor size ≥10 mm were independent risk factors for central LNM.ConclusionThe autoimmune response of HT seems to reduce the central lymph node metastasis of HT PTCs. Age < 55 and tumor size ≥10 mm were independent risk factors of central lymph node metastasis in HT PTCs.

【 授权许可】

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