Mn doped Prussian blue nanoparticles for T1/T2 MR imaging, PA imaging and Fenton reaction enhanced mild temperature photothermal therapy of tumor

Journal of Nanobiotechnology

Di Zhang¹  Zhide Zhang¹  Ruiyuan Liu¹  Quan Tao¹  Li Qi¹  Sheng Ye¹  Genghan He¹ 

[1] Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, 510515, Guangzhou, Guangdong, China;

关键词: MR imaging;    Photoacoustic imaging;    Mild temperature photothermal therapy;    Chemodynamic therapy;    Fenton reaction;   

DOI  :  10.1186/s12951-021-01235-2

来源: Springer

【 摘 要 】

BackgroundCombining the multimodal imaging and synergistic treatment in one platform can enhance the therapeutic efficacy and diagnosis accuracy.ResultsIn this contribution, innovative Mn-doped Prussian blue nanoparticles (MnPB NPs) were prepared via microemulsion method. MnPB NPs demonstrated excellent T1 and T2 weighted magnetic resonance imaging (MRI) enhancement in vitro and in vivo. The robust absorbance in the near infrared range of MnPB NPs provides high antitumor efficacy for photothermal therapy (PTT) and photoacoustics imaging property. Moreover, with the doping of Mn, MnPB NPs exhibited excellent Fenton reaction activity for chemodynamic therapy (CDT). The favorable trimodal imaging and Fenton reaction enhanced mild temperature photothermal therapy in vitro and in vivo were further confirmed that MnPB NPs have significant positive effectiveness for integration of diagnosis and treatment tumor.ConclusionsOverall, this Mn doped Prussian blue nanoplatform with multimodal imaging and chemodynamic/mild temperature photothermal co-therapy provides a reliable tool for tumor treatment.Graphical Abstract

【 授权许可】

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