Bovine serum albumin-templated nanoplatform for magnetic resonance imaging-guided chemodynamic therapy

Journal of Nanobiotechnology

Xinhong He¹  Bingxin Gu²  QiFeng Wang³  Dalong Ni⁴  Hongbo Gao⁵  Weijun Peng⁵  Wei Tang⁵ 

[1] 0000 0001 0125 2443, grid.8547.e, Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China;0000 0004 1808 0942, grid.452404.3, Department of Interventional Radiology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China;0000 0001 0125 2443, grid.8547.e, Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China;0000 0004 1808 0942, grid.452404.3, Department of Nuclear Medicine, Fudan University Shanghai Cancer Center, 200032, Shanghai, China;Shanghai Engineering Research Center of Molecular Imaging Probes, 200032, Shanghai, China;0000 0001 0125 2443, grid.8547.e, Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China;0000 0004 1808 0942, grid.452404.3, Department of Pathology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China;0000 0001 0701 8607, grid.28803.31, Departments of Radiology and Medical Physics, University of Wisconsin, 53705, Madison, WI, USA;0000 0004 1808 0942, grid.452404.3, Department of Radiology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China;0000 0001 0125 2443, grid.8547.e, Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China;

关键词: Chemodynamic therapy;    GSH;    BSA-templated;    MRI;   

DOI  :  10.1186/s12951-019-0501-3

来源: publisher

【 摘 要 】

BackgroundNanotechnology in medicine has greatly expanded the therapeutic strategy that may be explored for cancer treatment by exploiting the specific tumor microenvironment such as mild acidity, high glutathione (GSH) concentration and overproduced hydrogen peroxide (H2O2). Among them, tumor microenvironment responsive chemodynamic therapy (CDT) utilized the Fenton or Fenton-like reaction to produce excess hydroxyl radical (·OH) for the destruction of tumor cells. However, the produced ·OH is easily depleted by the excess GSH in tumors, which would undoubtedly impair the CDT’s efficiency. To overcome this obstacle and enhance the treatment efficiency, we design the nanoplatforms for magnetic resonance imaging (MRI)-guided CDT.ResultsIn this study, we applied the bovine serum albumin (BSA)-templated CuS:Gd nanoparticles (CuS:Gd NPs) for MRI-guided CDT. The Cu2+ in the CuS:Gd NPs could be reduced to Cu+ by GSH in tumors, which further reacted with H2O2 and triggered Fenton-like reaction to simultaneously generate abundant ·OH and deplete GSH for tumor enhanced CDT. Besides, the Gd3+ in CuS:Gd NPs endowed them with excellent MRI capability, which could be used to locate the tumor site and monitor the therapy process preliminarily.ConclusionsThe designed nanoplatforms offer a major step forward in CDT for effective treatment of tumors guided by MRI.

【 授权许可】

CC BY