Total magnetic resonance imaging of cerebral small vessel disease burden predicts dysphagia in patients with a single recent small subcortical infarct

BMC Neurology

Ye Yao¹  Shanshan Diao²  Dongxue Ding²  Xiuying Cai²  Yidan Li²  Xiang Tang²  Juehua Zhu²  Yun Zhou²  Lulu Zhang²  Yan Kong²  Qi Fang² 

[1] Department of Biostatistics, School of Public Health, Fudan University, No. 130 Dongan Road, 200032, Shanghai, China;National Clinical Research Center for Aging and Medicine, Huashan, Shanghai, China;Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China;Hospital, Fudan University, No 12 Wulumuqi Zhong Road, 200040, Shanghai, China;Department of Neurology, First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, 215006, Suzhou, Jiangsu, China;

关键词: Acute ischemic stroke;    Recent small subcortical infarct;    Magnetic resonance imaging;    Small vessel disease;    Post-stroke dysphagia;   

DOI  :  10.1186/s12883-021-02518-9

来源: Springer

【 摘 要 】

BackgroundThis study was performed to identify the association between the total magnetic resonance imaging burden of small vessel disease and the occurrence of post-stroke dysphagia in patients with a single recent small subcortical infarct (RSSI).MethodsWe retrospectively identified all patients with a magnetic resonance imaging-confirmed single RSSI. The water-swallowing test and volume-viscosity swallow test were performed within the first 24 h following admission to assess swallowing. Demographic and clinical data were extracted from our stroke database. Based on brain magnetic resonance imaging, we independently rated the presence of cerebral microbleeds, lacunes, white matter hyperintensities and enlarged perivascular spaces. The presence of each small vessel disease feature was summed to determine the total small vessel disease burden, ranging from 0 to 4.ResultsIn total, 308 patients with a single RSSI were enrolled. Overall, 54 (17.5%) were diagnosed with post-stroke dysphagia. The risk factors related to post-stroke dysphagia included the following: older age, higher National Institute of Health Stroke Scale scores, higher C-reactive protein level and higher fibrinogen level. Based on multiple logistic regression, National Institute of Health Stroke Scale scores and total small vessel disease burden were independent risk factors of post-stroke dysphagia in patients with a single RSSI, after adjusting for age, gender, history of hypertension, C-reactive protein level and fibrinogen level.ConclusionsDysphagia in patients with a single RSSI was associated with a more severe total small vessel disease burden as reflected by MRI. Total MRI of cerebral small vessel disease burden may predict dysphagia in these patients. Furthermore, more severe total small vessel disease burden was associated with systemic inflammation.

【 授权许可】

CC BY