DNA methylation mediates the association between breastfeeding and early-life growth trajectories

Clinical Epigenetics

Catherine Allard¹  Myriam Doyon¹  Samyukta Govinda Rajan²  Patrick O. McGowan³  Luigi Bouchard⁴  Yanyan Wu⁵  Marie-France Hivert⁶  Steven Lye⁷  Jingxiong Xu⁷  Denis Rustand⁸  Laurent Briollais⁹  Steven Matthews^1,10 

[1] Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Department of Biological Sciences, University of Toronto – Scarborough, Toronto, ON, Canada;Department of Medical Biology, CIUSSS Saguenay-Lac-Saint-Jean, Hôpital Universitaire de Chicoutimi, G7H 5H6, Saguenay, QC, Canada;Department of Biochemistry and Functional Genomics, Université de Sherbrooke, J1K 2R1, Sherbrooke, QC, Canada;Department of Public Health Sciences, University of Hawai’i at Manoa, Honolulu, HI, USA;Division of Chronic Disease Research Across the Life Course, Department of Population Medicine, Harvard Pilgrim Health Care Institute, Harvard Medical School, 02215, Boston, MA, USA;Department of Medicine, Université de Sherbrooke, J1H 5N4, Sherbrooke, QC, Canada;Diabetes Unit, Massachusetts General Hospital, 02114, Boston, MA, USA;Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street – Room 5-237, M5T 3L9, Toronto, ON, Canada;Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street – Room 5-237, M5T 3L9, Toronto, ON, Canada;Biostatistics Team, Bordeaux Population Health Center, ISPED, Centre INSERM U1219, Bordeaux, France;Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street – Room 5-237, M5T 3L9, Toronto, ON, Canada;Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada;Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 60, Murray street – Room 5-237, M5T 3L9, Toronto, ON, Canada;Department of Physiology, University of Toronto, Toronto, ON, Canada;

关键词: Breastfeeding;    DNA methylation;    microRNA;    BMI;    Obesity;    Mediation;    ALSPAC;    Child cohort;    DOHaD;   

DOI  :  10.1186/s13148-021-01209-z

来源: Springer

【 授权许可】

CC BY