Distribution of G6PD deficiency genotypes among Southeast Asian populations

Tropical Medicine and Health

Fumihiko Kawamoto¹  Indah S. Tantular² 

[1] Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia;Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan;Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia;Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia;

关键词: Glucose-6-phosphate dehydrogenase;    G6PD deficiency;    Genotype;    Distribution;    Southeast Asian population;   

DOI  :  10.1186/s41182-021-00387-z

来源: Springer

【 摘 要 】

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a group of X-linked, hereditary genetic disorders caused by mutations in the G6PD gene and results in functional variants of about 400 biochemical and clinical phenotypes. Among them, more than 215 genotypes have been identified so far. In this review, specific features of the genotype distribution in different communities and countries are discussed based on multiple reports and our molecular epidemiological studies of Southeast Asian countries. Particularly, in Indonesia, the frequency distribution of G6PD deficiency variants was distinct between western and eastern Indonesian populations, suggesting two different gene flows during Indonesian expansions.

【 授权许可】

CC BY