Parkinson’s disease with a typical clinical course of 17 years overlapped by Creutzfeldt–Jakob disease: an autopsy case report

BMC Neurology

Atsuko Takeuchi¹  Shin-ichiro Kubo²  Takeshi Taguchi³  Yuko Saito⁴  Tomoyasu Matsubara⁴  Renpei Sengoku⁵ 

[1] Department of Neurological Science, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, 980-8575, Sendai, Japan;Department of Neurology, Eisei Hospital, 583-15 Kunugidamachi, Hachioji, 193-0942, Tokyo, Japan;Department of Neurology, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, 193-0998, Tokyo, Japan;Department of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173-0015, Tokyo, Japan;Department of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, 173-0015, Tokyo, Japan;Department of Neurology, Daisan Hospital, The Jikei University School of Medicine, 4-11-1 Izumihoncho, Komae, 201-8601, Tokyo, Japan;

关键词: alpha-synuclein;    Creutzfeldt–Jakob disease;    Lewy bodies;    Parkinson’s disease;    prion;   

DOI  :  10.1186/s12883-021-02504-1

来源: Springer

【 摘 要 】

BackgroundLate-stage Parkinson’s disease (PD) often presents with neuropsychiatric symptoms such as dementia, psychosis, excessive daytime sleepiness, apathy, depression, and anxiety. However, neuropsychiatric symptoms are the cardinal features of Creutzfeldt–Jakob disease (CJD), raising the possibility that CJD may be an overlooked condition when it accompanies late-stage PD.Case presentationWe describe a female autopsy case of PD with a typical clinical course of 17 years, in which CJD overlapped with PD during the final year of the patient’s life. The patient died aged 85 years. Neuropathological features included widespread Lewy body-related α-synucleinopathy predominantly in the brainstem and limbic system, as well as the typical pathology of methionine/methionine type 1 CJD in the brain.ConclusionsOur case demonstrates the clinicopathological co-occurrence of PD and CJD in a sporadic patient. The possibility of mixed pathology, including prion pathology, should be taken into account when neuropsychiatric symptoms are noted during the disease course of PD.

【 授权许可】

CC BY