Potential drug–drug interactions in the era of integrase strand transfer inhibitors: a cross-sectional single-center study in Japan

Journal of Pharmaceutical Health Care and Sciences

Hiroshi Ikeda¹  Masayoshi Kobune¹  Tomoko Kimyo²  Manabu Kitagawa²  Ryosuke Matamura²  Hiromasa Nakata²  Masahide Fukudo²  Satoshi Fujii²  Atsushi Miyamoto²  Yusuke Kunimoto² 

[1] Department of Hematology, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, 060-8543, Sapporo, Japan;Department of Pharmacy, Sapporo Medical University Hospital, South-1, West-16, Chuo-ku, 060-8543, Sapporo, Japan;

关键词: HIV;    Potential drug–drug interaction;    Antiretroviral therapy;    Integrase strand transfer inhibitors;    Polypharmacy;   

DOI  :  10.1186/s40780-021-00226-7

来源: Springer

【 摘 要 】

BackgroundPotential drug–drug interactions (PDDIs) commonly occur because of aging and comorbidities in people living with human immunodeficiency virus (HIV; PLWH). Protease inhibitors and non-nucleoside reverse transcriptase inhibitors have been reported to cause PDDIs in these patients. However, there are few reports of PDDIs in the era of treatment using integrase strand transfer inhibitors. Therefore, we investigated PDDIs in Japanese PLWH receiving antiretroviral drugs (ARVs).MethodsThis was a cross-sectional observational study conducted in Japanese outpatients. All eligible patients who had received ARV therapy for at least 48 weeks were enrolled. The primary endpoint was the incidence of PDDIs detected using the Lexicomp® interface.ResultsOf the 71 eligible patients, 51 (71.8%) were prescribed concomitant non-ARV medications. In 21 patients (29.6%), PDDIs with the potential to reduce the effects of ARVs occurred, although the HIV load was suppressed in all cases. Polypharmacy (the use of ≥5 non-ARVs) was observed in 25 patients (35.2%). There was a significantly higher median number of non-ARV medications in the PDDI group than in the non-PDDI group (6 vs. 3, P <  0.001). Furthermore, the proportion of patients on polypharmacy was significantly higher in those with PDDIs than in those without PDDIs (81.0% vs. 26.7%, P <  0.001).ConclusionsThe incidence of PDDIs is relatively high in Japanese PLWH, even in the era of treatment using integrase strand transfer inhibitors. Therefore, it is important for patients and health care providers to be constantly aware of PDDIs associated with ARV treatment.

【 授权许可】

CC BY