Preparation, toxicity reduction and radiation therapy application of gold nanorods

Journal of Nanobiotechnology

Xinyue Li¹  Suxia Han¹  Lina Xie¹  Chengchao Chu²  Tianzi Zhang³  Wen Cai³  Xujia Zhang³  Yingqi Dong³  Gang Liu⁴ 

[1] Department of Radiation Oncology, The First Affiliated Hospital, Xi’an Jiaotong University, 710061, Xi’an, Shaanxi, China;Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, 361102, Xiamen, Fujian, China;Institute of Medical Engineering, School of Basic Medical Sciences, Health Science Center, Xi’an Jiaotong University, 710061, Xi’an, Shaanxi, China;State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102, Xiamen, Fujian, China;

关键词: Gold nanorods (GNRs);    Preparation;    Toxicity reduction;    Radiation sensitization;    Radiation therapy;   

DOI  :  10.1186/s12951-021-01209-4

来源: Springer

【 摘 要 】

Gold nanorods (GNRs) have a broad application prospect in biomedical fields because of their unique properties and controllable surface modification. The element aurum (Au) with high atomic number (high-Z) render GNRs ideal radiosensitive materials for radiation therapy and computed tomography (CT) imaging. Besides, GNRs have the capability of efficiently converting light energy to heat in the near-infrared (NIR) region for photothermal therapy. Although there are more and more researches on GNRs for radiation therapy, how to improve their biocompatibility and how to efficiently utilize them for radiation therapy should be further studied. This review will focuse on the research progress regarding the preparation and toxicity reduction of GNRs, as well as GNRs-mediated radiation therapy.Graphical Abstract

【 授权许可】

CC BY