Overall survival and prognostic factors prostate cancer in Kurdistan Province-Iran: a population-based study (2011-2018)

BMC Cancer

Hedyeh Zafari¹  Sima Tozandehjani¹  Parisa Hassani¹  Mahshid Mohammadian²  Bushra Zareie³  Fatemeh Gholami⁴  Sonia Shahsavari⁵  Mohammad Aziz Rasouli⁶  Ghobad Moradi⁶  Heshmatollah Sofimajidpour⁷ 

[1] Department of Biological Sciences, Faculty of Science, University of Kurdistan, Sanandaj, Iran;Department of Clinical Biochemistry, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran;Department of Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran;Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran;Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran;Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran;Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran;Department of Urology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran;

关键词: Survival;    Prostate Cancer;    Population-Based Study;    Kurdistan;    Iran;   

DOI  :  10.1186/s12885-021-09078-8

来源: Springer

【 摘 要 】

BackgroundThe population-based survival rate is affected by the quality and effectiveness of health care systems. Overall, the survival of prostate cancer (PC) patients has improved over the past two decades worldwide. This study aimed to determine the overall survival rate and correlate it with the prognostic factors in patients with PC diagnosed in Kurdistan province.MethodsIn a retrospective cohort study, 410 PC patients registered in Kurdistan province population-based cancer registry from March 2011 to 2018 were recruited. Kaplan–Meier method and log-rank test were used to analyze the overall survival rates of PC patients. A Multivariate Cox regression model was used to determine adjusted hazard ratios for different variables.ResultsOf 410 patients with PC, 263 (64.1%) died within seven years due to the disease. The 1, 3, and 5 years survival rates were 93, 64.1, and 40.7%, respectively. According to the results of multiple Cox regression, the following factors were significantly related to PC survival: age at diagnosis (≥81-years old) (HR=2.23, 95% CI: 1.23-4.42) and 71-80 years old was (HR=1.26, 95% CI: 1.12-2.31), occupation (employee) (HR=0.42, 95% CI: 0.20–0.87), educational level: academic (HR=0.78, 95% CI: 0.64–0.91), AJCC stage of disease (HR=2.18, 95% CI: 1.9–3.68), Gleason score ≥ 9 (HR=7.12, 95% CI: 5.35–10.28), and Gleason score= 8 (HR=4.16, 95% CI: 2.50–6.93). There was less mortality rate among the patients who had received active care, radical prostatectomy, radiotherapy, combined treatment, and orchiectomy had a lower mortality rate than those who received no treatment (P<0.05).ConclusionsThis study demonstrated that factors such as age at diagnosis, level of education, occupation, AJCC stage of disease, Gleason score, and type of treatments were influential factors in the survival of PC patients in Kurdistan province and needed more attention.

【 授权许可】

CC BY