Underlying mechanism of hemodynamics and intracranial aneurysm

Chinese Neurosurgical Journal

Qingsong Wang¹  Zhiwen Lu²  Jianmin Liu²  Gaici Xue²  Yin Luo²  Xiaoxi Zhang²  Qiao Zuo²  Qinghai Huang²  Yazhou Yan²  Zhangwei Zeng²  Haishuang Tang³  Fengfeng Xu⁴ 

[1] Department of Cardiology, the First Medical Centre, Chinese PLA General Hospital, 100853, Beijing, People’s Republic of China;Department of Neurosurgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, 200433, Shanghai, People’s Republic of China;Department of Neurosurgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, 200433, Shanghai, People’s Republic of China;Naval Medical Center of PLA, Naval Military Medical University, 200050, Shanghai, People’s Republic of China;Naval Medical Center of PLA, Naval Military Medical University, 200050, Shanghai, People’s Republic of China;

关键词: Hemodynamics;    Inflammation;    Atherosclerosis;    Intracranial aneurysm;   

DOI  :  10.1186/s41016-021-00260-2

来源: Springer

【 摘 要 】

In modern society, subarachnoid hemorrhage, mostly caused by intracranial aneurysm rupture, is accompanied by high disability and mortality rate, which has become a major threat to human health. Till now, the etiology of intracranial aneurysm has not been entirely clarified. In recent years, more and more studies focus on the relationship between hemodynamics and intracranial aneurysm. Under the physiological condition, the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood vessels. When the blood vessels are stimulated by the continuous abnormal blood flow, the functional structure of the blood vessels changes, which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial aneurysm. This review will focus on the relationship between hemodynamics and intracranial aneurysms, will discuss the mechanism of occurrence and development of intracranial aneurysms, and will provide a new perspective for the research and treatment of intracranial aneurysms.

【 授权许可】

CC BY