A patient with Turner syndrome received the percutaneous vertebroplasty seven times: a case report and literature review

European Journal of Medical Research

Longyu Li¹  Nan Zhao¹  Hongwei Kou¹  Zhengpei Liu¹  Zongmian Song¹  Sailei Zheng¹  Zhe Zhao¹  Songfeng Chen¹  Hongjian Liu¹  Yifang Shi¹  Miaoheng Yan¹  Zikuan Leng¹  Guowei Shang¹ 

[1] Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe East Road, Zhengzhou, China;

关键词: Osteoporosis;    Turner syndrome;    Percutaneous vertebroplasty;    Vertebral compression fractures;    Estrogen;    Gut microbiome;   

DOI  :  10.1186/s40001-021-00617-4

来源: Springer

【 摘 要 】

BackgroundTurner syndrome (TS) is characterized as the complete or partial absence of one X chromosome and is an extremely rare disease affecting approximately 1:2500 live female births. Though the prevalence of osteoporosis among women with TS is estimated to be around 55–64% and they suffer more frequently from fractures than normal, few reports concerning TS patients with osteoporosis are able to be seen due to tiny number of patients.Case presentationHere, we report a rare case of TS with osteoporosis, who has undergone percutaneous vertebroplasty (PVP) seven times because of several vertebral compression fractures (VCFs). G-banded karyotype analysis was performed and the result was 45,X[43]/47,XXX[17], indicating that the patient was a mosaicism of TS karyotype and Trisomy X syndrome karyotype. TS is the underlying cause of low level of estrogen for this patient. The interaction of aging, estrogen deficiency and intestinal dysbacteriosis leads to her severe osteoporosis and multi-segmental VCFs. The aim of this report is to provide recommendations regarding the management of TS patients with osteoporosis by reviewing the clinical presentation of TS, the influence of estrogen deficiency in osteoporosis, etc.ConclusionsEarly diagnosis and hormone replacement treatment are essential for TS patients to prevent osteoporosis and reduce the risk of fractures. This is a rare case report describing TS patient with severe osteoporosis and VCFs.

【 授权许可】

CC BY