Helicobacter pylori antibodies and multiple sclerosis: a single-center study and a short review of the literature

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Andrés Aurelio León-Peña¹  Iván Murrieta-Álvarez²  Juan Carlos Olivares-Gazca²  Guillermo J. Ruiz-Delgado³  Guillermo J. Ruiz-Argüelles³  Miguel Antonio López-Trujillo⁴  Alejandra Carmina Córdova-Ramírez⁵  Gilberto David Elias-de-la-Cruz⁵  Montserrat Rivera-Álvarez⁵  Yahveth Cantero-Fortiz⁶ 

[1] Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530, Puebla, Mexico;Benemérita Universidad Autónoma de Puebla, Puebla, Mexico;Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530, Puebla, Mexico;Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico;Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530, Puebla, Mexico;Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico;Laboratorios Clínicos de Puebla, Puebla, Mexico;Laboratorios Clínicos de Puebla, Puebla, Mexico;Universidad Popular Autónoma del Estado de Puebla, Puebla, Mexico;Universidad de las Américas Puebla, Puebla, Mexico;Centro de Hematología y Medicina Interna de Puebla, 8B Sur 3710, 72530, Puebla, Mexico;

关键词: MS;    Helicobacter pylori;    Seroprevalence;    Epidemiology;   

DOI  :  10.1186/s41983-021-00419-9

来源: Springer

【 摘 要 】

BackgroundMultiple sclerosis is an immune-mediated disease which has been associated to a great variety of mechanisms that could influence its pathogenesis. Numerous reports in the medical literature suggest that Helicobacter pylori may be a mediator of the disease. However, it is unknown if there is any clear association between MS and HP.ResultsWe studied 144 persons with multiple sclerosis prospectively enrolled in our hematopoietic stem cell transplantation program. In 144 persons, 14% patients were positive for IgG-HP whereas 86% were negative, 8.3% pwMS were IgM-HP positive while 91.6% pwMS were negative, 18% patients were positive and 82% negative for IgA-HP. Significantly lower concentrations of anti-HP IgG were found in RRMS in comparison with SPMS (− 28.5, 95% CI 4.3–52.7). While concentrations of anti-HP IgA were significantly lower in SPMS in comparison with RRMS (0.54, 95% CI 0.1–0.9). In a multivariate analysis, positivity rate of anti-HP IgG was found to be higher in SPMS patients (OR 4.7, 95% CI 1.1–19.6).ConclusionsThere was a negative correlation between the presence of anti-HP antibodies and MS. Further larger studies with specific laboratory testing methods are needed to discard or confirm the potential role of anti-HP antibodies as protective for MS.

【 授权许可】

CC BY