IL-6 and IL-10 gene polymorphisms and cirrhosis of liver risk from a comprehensive analysis

BMC Endocrine Disorders

Weizhen Fang¹  Chaohui Duan¹  Minghui Zheng¹  Rui Ding¹  Hua Zeng¹  Yan Huang²  Yuanyang Mi³  Menglei Yu⁴ 

[1] Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, People’s Republic of China;Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Chinese Ministry of Education, 510080, Guangzhou, Guangdong, People’s Republic of China;Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Rd, 214000, Wuxi, People’s Republic of China;Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, 510120, Guangzhou, China;Emergency Department, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China;

关键词: Interleukin-10;    Interleukin-6;    Cirrhosis of liver;    Polymorphism;    meta-analysis;    Risk;   

DOI  :  10.1186/s12902-021-00906-3

来源: Springer

【 摘 要 】

BackgroundDifferent inflammatory and immune cytokines play a key role in the development of cirrhosis of liver (CL). To investigate the association between interleukin-6,10 (IL-6,10) genes polymorphisms and CL risk through comparison of the allele and genotype distribution frequencies by meta-analysis.MethodsA literature search covered with the PubMed, Embase, Cochrane Library, Web of Science, Google Scholar, SinoMed (CNKI and Wanfang) through 20th April, 2021. Odds ratios (OR) and 95% confidence intervals (CI) were used to assess the strength of associations.ResultsAfter a comprehensive search, three common polymorphisms (rs1800872, rs1800871, rs1800896) in IL-10 gene were selected, and three common polymorphisms (rs1800795, rs1800796, rs1800797) in IL-6 gene were also identified. The important finding was that IL-10 rs1800872 was a risk factor for CL development. For example, there has a significantly increased relationship between rs1800872 polymorphism and CL both in the whole group (OR: 1.30, 95%CI: 1.01–1.67 in heterozygote model), Asian population (OR: 1.40, 95%CI: 1.03–1.88 in heterozygote model) and hospital-based source of control (OR: 1.40, 95%CI: 1.01–1.96 in dominant model). In addition, significant association was found between rs1800896 and primary biliary cirrhosis subtype disease (OR: 1.30, 95%CI: 1.01–1.68 in allelic contrast model). No association was observed in all three polymorphisms in IL-6 gene.ConclusionOur present study suggests that the IL-10 rs1800872 and rs1800896 polymorphisms is potentially associated with the risk of CL susceptibility.

【 授权许可】

CC BY