Evidence of co-circulation of multiple arboviruses transmitted by Aedes species based on laboratory syndromic surveillance at a health unit in a slum of the Federal District, Brazil

Parasites & Vectors

Lorena Aparecida Gonçalves de Noronha¹  Gustavo Adolfo Sierra Romero²  Ana Paula Sampaio Cardoso²  Paulo Rufalco-Moutinho²  Tayane Ferreira Nobre²  Tatyane de Souza Cardoso Quintão²  Wildo Navegantes de Araújo³  Rodrigo Haddad³  Mateus de Paula von Glehn⁴  Marco Aurélio Bellocchio Júnior⁴  Daiani Cristina Cilião-Alves⁵ 

[1] Ceilândia Faculty, University of Brasília, Federal District, Brazil;Center of Tropical Medicine, University of Brasília, Federal District, Brazil;Center of Tropical Medicine, University of Brasília, Federal District, Brazil;Ceilândia Faculty, University of Brasília, Federal District, Brazil;Federal District Department of Health, Federal District, Brazil;UNIEURO University Center, Federal District, Brazil;

关键词: Arboviruses;    Dengue;    Chikungunya;    Aedes;    Syndromic surveillance;    Traditional surveillance;    Brazil;   

DOI  :  10.1186/s13071-021-05110-9

来源: Springer

【 摘 要 】

BackgroundVector-borne diseases, especially arboviruses transmitted by Aedes sp. mosquitos, should be a health policy priority in Brazil. Despite this urgency, there are significant limitations in the traditional surveillance system, mainly in vulnerable areas. This study aimed to investigate the circulation of dengue (DENV), Zika (ZIKV), and chikungunya viruses (CHIKV) by laboratory syndromic surveillance (LSS) in a slum area of the Federal District of Brazil, comparing the results with traditional surveillance data.MethodsLSS for acute febrile and/or exanthematous symptoms was developed at a health unit of Cidade Estrutural, in order to identify the circulation of arboviruses transmitted by Aedes sp. mosquitos. Between June 2019 and March 2020, 131 valid participants were identified and sera tested by reverse transcription polymerase chain reaction (RT-PCR) for DENV (by serotype), ZIKV, and CHIKV acute infection and by immunoglobulin M enzyme-inked immunosorbent assay (ELISA-IgM) for DENV and CHIKV 15–21 days after symptom onset, when the participant reported no respiratory signs (cough and/or coryza). The results obtained were compared with traditional surveillance data for the study area and period.ResultsAt least three DENV-1 (2.3%), four DENV-2 (3%), and one CHIKV (0.7%) cases were confirmed in the laboratory, showing evidence of hyperendemicity even though LSS had not reached the historic peak dengue fever months in the Federal District (April–May). When the results obtained here were compared with traditional surveillance, a significant discrepancy was observed, including underreporting of CHIKV infection.ConclusionsIn addition to the risks posed to the study population, the area investigated with its respective socio-environmental profile may be a potential site for spread of the virus, given the cosmopolitan presence of Aedes sp. and human mobility in the Federal District. It is also suggested that traditional epidemiological surveillance may be reporting acute viral infections other than DENV as dengue fever, while underreporting other arboviruses transmitted by Aedes sp. mosquitos in the Federal District.Graphical Abstract

【 授权许可】

CC BY