ArVirInd—a database of arboviral antigenic proteins from the Indian subcontinent

PeerJ

article

Nitin Motilal Atre¹  Kalichamy Alagarasu¹  Pratip Shil¹ 

[1] Bioinformatics, ICMR National Institute of Virology Pune

关键词: Arboviruses;    Antigenic proteins;    Epitopes;    Indian subcontinent;    Database;    Dengue;    Chikungunya;    Japanese encephalitis;    West Nile;    Chandipura;   

DOI  :  10.7717/peerj.13851

学科分类：社会科学、人文和艺术（综合）

来源: Inra

【 摘 要 】

BackgroundStudies on antigenic proteins for arboviruses are important for providing diagnostics and vaccine development. India and its neighboring countries have a huge burden of arboviral diseases. Data mining for country-specific sequences from existing bioinformatics databases is cumbersome and time-consuming. This necessitated the development of a database of antigenic proteins from arboviruses isolated from the countries of the Indian subcontinent.MethodsArboviral antigenic protein sequences were obtained from the NCBI and other databases. In silico antigenic characterization was performed (Epitope predictions) and data was incorporated into the database. The front end was designed and developed using HTML, CSS, and PHP. For the backend of the database, we have used MySQL.ResultsA database, named ArVirInd, is created as a repository of information on curated antigenic proteins. This enlists sequences by country and year of outbreak or origin of the viral strain. For each entry, antigenic information is provided along with functional sites, etc. Researchers can search this database by virus/protein name, country, and year of collection (or in combination) as well as peptide search for epitopes. It is available publicly via the Internet at http://www.arvirind.co.in. ArVirInd will be useful in the study of immune informatics, diagnostics, and vaccinology for arboviruses.

【 授权许可】

CC BY