A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru

BMC Infectious Diseases

Janeth Picoy¹  Amber Shrestha²  Louis Grandjean³  Arturo Torres⁴  Jorge Coronel⁵  Robert H. Gilman⁶  David A. Moore⁷ 

[1] Department of Infectious Disease, Diresa Callao Jr, Colina #879, Bellavista, 07016, Lima, Peru;Department of Infectious Disease, Great Ormond Street Hospital for Children, WC1N 3JH, London, UK;Department of Infectious Disease, Great Ormond Street Hospital for Children, WC1N 3JH, London, UK;University College London, Gower St, Bloomsbury, WC1E 6BT, London, UK;Department of Infectious Disease, Imperial College London, South Kensington, SW7 2AZ, London, UK;Laboratorio de Investigación de Enfermedades Infecciosas, Universidad Peruana Cayetano Heredia: Lima, Lima, Peru;Laboratorio de Tuberculosis, Laboratorios de Investigación Y Desarrollo, Facultad de Ciencias Y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru;Department of International Health, School of Public Health, Johns Hopkins University, Baltimore, MD, USA;TB Centre, London School of Hygiene & Tropical Medicine, WC1E 7HT, London, UK;

关键词: Mycobacterium tuberculosis;    Zoonotic disease;    Caprae;    Bovis;    Case report;   

DOI  :  10.1186/s12879-021-06944-5

来源: Springer

【 摘 要 】

BackgroundThe Tuberculosis (TB) burden in Peru is significant with respect to both disease morbidity and mortality. Furthermore the recent diversification of farming enterprise to include a wide range of animal species has necessitated the consideration of members of the Mycobacterium Tuberculosis Complex (MTBC) with the potential for zoonotic transmission. M. bovis and M. caprae, a lesser known member of the MTBC exhibit an exceptionally wide host spectrum in animals and are capable of causing disease in humans. M. bovis has a predictable resistance profile which includes resistance to pyrazinamide. Thus, failure to identify M. bovis as the causative agent in reported TB cases leads to higher levels of treatment failure and contributes to the transmission of drug-resistant TB.Case presentationReported here are the clinical presentations, investigations and treatment histories of two patients identified from a population level genotyping study in Lima, Peru that were at the time of treatment thought to be M. tuberculosis patients but in retrospect were spectated using whole genome sequencing as M. caprae and M. Bovis.ConclusionsThe cases reported here constitute convincing evidence that M. caprae and M. bovis are causative agents of TB infection in humans in Peru and underscore the importance of species-level MTBC member identification to effectively control and treat zoonotic TB. Furthermore these cases highlight the challenges of using clinical risk factors to identify cases of zoonotic TB in humans as their clinical presentation and transmission history is often difficult to distinguish from anthroponotic TB.

【 授权许可】

CC BY