Mitochondrial H2Sn-Mediated Anti-Inflammatory Theranostics

Nano-Micro Letters

Won Young Kim¹  Jong Seung Kim¹  Miae Won¹  Seyoung Koo¹  Xingcai Zhang² 

[1] Department of Chemistry, Korea University, 02841, Seoul, Korea;John A. Paulson School of Engineering and Applied Sciences, Harvard University, 02138, Cambridge, MA, USA;School of Engineering, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA;

关键词: Theranostics;    Anti-inflammation;    Mitochondria;    Hydrogen polysulfides;   

DOI  :  10.1007/s40820-021-00689-1

来源: Springer

【 摘 要 】

tsTheranostic agent 1 (TA1) was successfully developed to provide dual functions: anti-inflammatory therapy and precise diagnosis.TA1 selectively reacts with H2Sn in the mitochondria in response to inflammatory reactions to simultaneously produce both indomethacin as a drug and ring-opened fluorescence-on Rhodol.Theranostic behavior of TA1 was proven by in vitro and in vivo imaging.TA1 reveals inflammatory site-selective drug release followed by significant therapeutic effects and is highly applicable in vivo model therapeutics for the inflammatory disease.

【 授权许可】

CC BY