FLIM as a Promising Tool for Cancer Diagnosis and Treatment Monitoring

Nano-Micro Letters

Minghua Wu¹  Yuzhen Ouyang²  Zhiming M. Wang³  Zongwen Liu⁴  Yanping Liu⁵ 

[1] Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 410013, Changsha, Hunan, People’s Republic of China;School of Physics and Electronics, Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, Central South University, 932 South Lushan Road, 410083, Changsha, Hunan, People’s Republic of China;Hunan Provincial Tumor Hospital and the Affiliated Tumor Hospital of Xiangya Medical School, Central South University, 410013, Changsha, Hunan, People’s Republic of China;School of Physics and Electronics, Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, Central South University, 932 South Lushan Road, 410083, Changsha, Hunan, People’s Republic of China;The Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, 410008, Changsha, Hunan, People’s Republic of China;Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, 610054, Chengdu, Sichuan, People’s Republic of China;School of Chemical and Biomolecular Engineering, The University of Sydney, 2006, Sydney, NSW, Australia;School of Physics and Electronics, Hunan Key Laboratory for Super-Microstructure and Ultrafast Process, Central South University, 932 South Lushan Road, 410083, Changsha, Hunan, People’s Republic of China;Shenzhen Research Institute of Central South University, A510a, Virtual University Building, Nanshan District, Southern District, High-tech Industrial Park, Yuehai Street, Shenzhen, People’s Republic of China;State Key Laboratory of High-Performance Complex Manufacturing, Central South University, 932 South Lushan Road, 410083, Changsha, Hunan, People’s Republic of China;

关键词: Fluorescence lifetime imaging microscopy;    Förster resonance energy transfer;    Reduced form of nicotinamide adenine dinucleotide;    Biosensors;    Cancer;   

DOI  :  10.1007/s40820-021-00653-z

来源: Springer

【 摘 要 】

tsFluorescence lifetime imaging microscopy (FLIM) applications for cancer diagnosis and treatment monitoring combined with reduced form of nicotinamide adenine dinucleotide, Förster resonance energy transfer (FRET), and biosensors are reviewed.Principles of FLIM, previous clinical applications, and development history are introduced.The current challenges and prospects for the potential of FLIM for cancer diagnosis and promotion of the effect of anti-cancer treatment are discussed.

【 授权许可】

CC BY