Targeted cognitive game training enhances cognitive performance in multiple sclerosis patients treated with interferon beta 1-a

Journal of NeuroEngineering and Rehabilitation

Franck Tarpin-Bernard¹  Sapir Dreyer-Alster²  Keren Gutman²  Ran Achiron²  Roy Aloni³  Shay Menascu⁴  Mark Dolev⁴  David Magalashvili⁴  Anat Achiron⁵  Gil Harari⁶ 

[1] HAPPYneuron, Villeurbanne, France;Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel;Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel;Department of Behavioral Sciences and Psychology, Ariel University, Ariel, Israel;Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel;Sackler School of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel;Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel;Sackler School of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel;Laura Schwarz-Kipp Research of Autoimmune Diseases, Sackler School of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel;School of Public Health, University of Haifa, Haifa, Israel;

关键词: Multiple sclerosis;    Cognition;    Information processing speed;    Executive function;    Games;    Training;    Interferon-beta-1-a;    Plasticity;   

DOI  :  10.1186/s12984-021-00968-3

来源: Springer

【 摘 要 】

BackgroundPrevention of cognitive decline in Multiple Sclerosis (MS) is of major importance. We explored the effect of a 6 months computerized game training program on cognitive performance in MS patients with mild cognitive impairment.MethodsThis was a single-center, randomized prospective study. We enrolled in this study 100 eligible MS patients treated with Interferon-beta-1a (Rebif). All had mild cognitive impairment in either executive function or information processing speed. Patients were randomized 1:1 to either use the cognitive games platform by HappyNeuron (HN) or receive no intervention. Executive function and information processing speed scores were measured at 3 and 6 months from baseline to evaluate the effect of game training on cognitive scores.ResultsIn both executive function and information processing speed, the game Training group showed significant improvement after 3 and 6 months. The Non-Training group showed mild deterioration in both domains at 3 months, and further deterioration that became significant at 6 months in executive function. Furthermore, at 6 months, the percent of patients in the Training group that improved or remained stable in both cognitive domains was significantly higher compared to the Non-Training group.ConclusionsOur findings suggest that cognitive game training has a beneficial effect on cognitive performance in MS patients suffering from mild cognitive impairment. While further evaluation is required to assess the longevity of that effect, we nonetheless recommend to MS patients to be engaged in cognitive gaming practice as part of a holistic approach to treating their condition.

【 授权许可】

CC BY