The Kaiser Permanente Research Bank Cancer Cohort: a collaborative resource to improve cancer care and survivorship

BMC Cancer

Alan Bauck¹  Sheila Weinmann¹  Stacey A. A. Honda²  Deborah R. Young³  Stephen K. Van Den Eeden⁴  Terrence Chinn⁴  Christina L. Clarke⁵  Heather Spencer Feigelson⁵  Larissa L. White⁵  Shauna Goldberg Scott⁵  Andrea N. Burnett-Hartman⁵  Sarah Rowell⁶  Elizabeth A. McGlynn⁷  Alexander Lituev⁸  Aruna Kamineni⁹  Monica Ter-Minassian^1,10 

[1] Center for Health Research, Kaiser Permanente, 3800 N. Interstate Ave, 97227, Portland, OR, USA;Center for Integrated Healthcare Research and Hawai’i Permanente Medical Group, Kaiser Permanente, 501 Alakawa St Suite 201, 96817, Honolulu, HI, USA;Department of Research and Evaluation, Kaiser Permanente, 100 S. Los Robles Avenue, 91101, Pasadena, CA, USA;Division of Research, Kaiser Permanente, 2000 Broadway, 94612, Oakland, CA, USA;Institute for Health Research, Kaiser Permanente, 2550 S. Parker Rd, Suite 200, 80014, Aurora, CO, USA;Kaiser Permanente Program Office, 1800 Harrison, 16th floor, 94612, Oakland, CA, USA;Kaiser Permanente Research & Quality Measurement and Kaiser Permanente Research Bank, 100 S. Los Robles, 3rd floor, 91101, Pasadena, CA, USA;Kaiser Permanente Research Bank, Kaiser Permanente, 1795 A Second St, 94710, Berkeley, CA, USA;Kaiser Permanente Washington Health Research Institute, 1730 Minor Ave Suite 1600, 98101, Seattle, WA, USA;Mid-Atlantic Permanente Research Institute, Kaiser Permanente, 2101 East Jefferson St, 3 West, 20852, Rockville, MD, USA;

关键词: Cancer;    Survivorship;    Cohort study;    Disparities;    Genetic;   

DOI  :  10.1186/s12885-022-09252-6

来源: Springer

【 摘 要 】

BackgroundThe Kaiser Permanente Research Bank (KPRB) is collecting biospecimens and surveys linked to electronic health records (EHR) from approximately 400,000 adult KP members. Within the KPRB, we developed a Cancer Cohort to address issues related to cancer survival, and to understand how genetic, lifestyle and environmental factors impact cancer treatment, treatment sequelae, and prognosis. We describe the Cancer Cohort design and implementation, describe cohort characteristics after 5 years of enrollment, and discuss future directions.MethodsCancer cases are identified using rapid case ascertainment algorithms, linkage to regional or central tumor registries, and direct outreach to KP members with a history of cancer. Enrollment is primarily through email invitation. Participants complete a consent form, survey, and donate a blood or saliva sample. All cancer types are included.ResultsAs of December 31, 2020, the cohort included 65,225 cases (56% female, 44% male) verified in tumor registries. The largest group was diagnosed between 60 and 69 years of age (31%) and are non-Hispanic White (83%); however, 10,076 (16%) were diagnosed at ages 18–49 years, 4208 (7%) are Hispanic, 3393 (5%) are Asian, and 2389 (4%) are Black. The median survival time is 14 years. Biospecimens are available on 98% of the cohort.ConclusionsThe KPRB Cancer Cohort is designed to improve our understanding of treatment efficacy and factors that contribute to long-term cancer survival. The cohort’s diversity - with respect to age, race/ethnicity and geographic location - will facilitate research on factors that contribute to cancer survival disparities.

【 授权许可】

CC BY