Nanozymes-recent development and biomedical applications

Journal of Nanobiotechnology

Yan Wang¹  Hongying Chen¹  Huifang Li¹  Xiangyi Ren¹  Yabing Zhang²  Dongxu Chen²  Xi Li²  Minfeng Huo³ 

[1] Core Facilities of West China Hospital, Sichuan University, 610041, Chengdu, China;Department of Anesthesiology, West China Hospital of Sichuan University, 610041, Chengdu, China;Shanghai Tenth People’s Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, 200072, Shanghai, People’s Republic of China;State Key Laboratory of High Performance Ceramics and Superfine Microstructure; Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences (2021RU012), Shanghai Institute of Ceramics Chinese Academy of Sciences, 200050, Shanghai, People’s Republic of China;

关键词: Nanozyme;    Oxidative stress;    Reactive oxygen species;    Disease therapy;   

DOI  :  10.1186/s12951-022-01295-y

来源: Springer

【 摘 要 】

Nanozyme is a series of nanomaterials with enzyme-mimetic activities that can proceed with the catalytic reactions of natural enzymes. In the field of biomedicine, nanozymes are capturing tremendous attention due to their high stability and low cost. Enzyme-mimetic activities of nanozymes can be regulated by multiple factors, such as the chemical state of metal ion, pH, hydrogen peroxide (H2O2), and glutathione (GSH) level, presenting great promise for biomedical applications. Over the past decade, multi-functional nanozymes have been developed for various biomedical applications. To promote the understandings of nanozymes and the development of novel and multifunctional nanozymes, we herein provide a comprehensive review of the nanozymes and their applications in the biomedical field. Nanozymes with versatile enzyme-like properties are briefly overviewed, and their mechanism and application are discussed to provide understandings for future research. Finally, underlying challenges and prospects of nanozymes in the biomedical frontier are discussed in this review.Graphical Abstract

【 授权许可】

CC BY