Risk of aortic aneurysm and aortic dissection with the use of fluoroquinolones in Korea: a nested case–control study

BMC Cardiovascular Disorders

Bonggi Kim¹  Eunmi Choi¹  Soo Youn Chung¹  Nayeong Son¹  Soon Young Han¹ 

[1]Korea Institute of Drug Safety and Risk Management, 6th FL, 30, Burim-ro 169beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Republic of Korea

关键词: Fluoroquinolone;    Aortic aneurysm;    Aortic dissection;    Drug safety;    Pharmacovigilance;    Adverse effect;   

DOI  :  10.1186/s12872-022-02488-x

来源: Springer

【 摘 要 】

BackgroundRecent studies have raised concern about the association of fluoroquinolones with an increased risk of aortic aneurysm and aortic dissection. We aimed to evaluate such risk in a Korean population.MethodsWe conducted a nested case–control study using data from the National Health Insurance Service collected from 2013 to 2017 in Korea. The study cohort included patients older than 40 years and excluded patients who had used fluoroquinolones or been diagnosed with aortic aneurysm, aortic dissection, or related diseases 1 year prior to the cohort entry date. We randomly matched four controls in the risk set with each case of aortic aneurysm and aortic dissection (same sex, age, and cohort entry date). We assessed the risk of aortic aneurysm and aortic dissection from fluoroquinolones and adjusted for potential confounders using a conditional logistic regression model.ResultsA total of 29,638 aortic aneurysm and aortic dissection patients were identified between 2014 and 2017. The use of fluoroquinolones within a year was associated with a 10% increased risk of aortic aneurysm and aortic dissection (adjusted odds ratio: 1.10, 95% CI 1.07–1.14, p < 0.05) compared with nonusers. The risk was higher in patients who had used fluoroquinolones within 60 days (adjusted odds ratio: 1.53, 95% CI 1.46–1.62, p < 0.05). The risk of aortic aneurysm and aortic dissection positively correlated with the cumulative dose and duration of fluoroquinolone therapy (p < 0.001).ConclusionsOur study provides real-world evidence of the risk of aortic aneurysm and aortic dissection from fluoroquinolones in Korea. Patients and medical professionals should be aware that fluoroquinolones can increase the risk of aortic aneurysm and aortic dissection, which may be acerbated by high dosage and duration of use.

【 授权许可】

CC BY