IKK-mediated CYLD phosphorylation and cellular redox activity

Molecular Medicine

Adnan Erol¹ 

[1] Silivri-Istanbul, Turkey;

关键词: CYLD;    IKK;    NRF2;    NF-κB;    RIPK1;   

DOI  :  10.1186/s10020-022-00439-y

来源: Springer

【 摘 要 】

Oxidative stress is important in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been described. However, contradictory explanations about the functioning of the mechanisms that will be effective in the pathogenesis require clarification.

【 授权许可】

CC BY