Repurposing the drug, ivermectin, in COVID-19: toxicological points of view

European Journal of Medical Research

Farshad M. Shirazi¹  Amir Nejatian²  Roya Mirzaei³  Shokouh Ghafari⁴  Samaneh Nakhaee⁵  Omid Mehrpour⁶ 

[1] Arizona Poison & Drug Information Center, College of Pharmacy and University of Arizona College of Medicine, University of Arizona, Tucson, AZ, USA;Department of Civil Eng., Sharif University of Technology, Tehran, Iran;Faculty of Pharmacy and Pharmaceutical Sciences, Islamic Azad University, Tehran Medical Sciences University (IAUTMU), Tehran, Iran;Venom and Biotherapeutic Molecules Lab., Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, 13169-43551, Tehran, Iran;Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran;Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran;Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran;Data Science Institute, Southern Methodist University, Dallas, TX, USA;

关键词: Ivermectin;    COVID-19;    SARS-CoV-2;    Coronavirus disease 2019;   

DOI  :  10.1186/s40001-022-00645-8

来源: Springer

【 摘 要 】

The global COVID-19 pandemic has affected the world’s population by causing changes in behavior, such as social distancing, masking, restricting people’s movement, and evaluating existing medication as potential therapies. Many pre-existing medications such as tocilizumab, ivermectin, colchicine, interferon, and steroids have been evaluated for being repurposed to use for the treatment of COVID-19. None of these agents have been effective except for steroids and, to a lesser degree, tocilizumab. Ivermectin has been one of the suggested repurposed medications which exhibit an in vitro inhibitory activity on SARS-CoV-2 replication. The most recommended dose of ivermectin for the treatment of COVID-19 is 150–200 µg/kg twice daily. As ivermectin adoption for COVID-19 increased, the Food and Drug Administration (FDA) issued a warning on its use during the pandemic. However, the drug remains of interest to clinicians and has shown some promise in observational studies. This narrative reviews the toxicological profile and some potential therapeutic effects of ivermectin. Based on the current dose recommendation, ivermectin appears to be safe with minimum side effects. However, serious questions remain about the effectiveness of this drug in the treatment of patients with COVID-19.

【 授权许可】

CC BY