Importance of TP53 codon 72 and intron 3 duplication 16 bp polymorphisms and their haplotypes in susceptibility to sarcopenia in Iranian older adults

BMC Geriatrics

Naeimehossadat Asmarian¹  Nima Montazeri-Najafabady²  Mohammad Hossein Dabbaghmanesh²  Alireza Estedlal²  Nasrin Nasimi³  Zahra Sohrabi³ 

[1] Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Sarcopenia;    p53;    Polymorphism;    Body composition;    Lipid profile;   

DOI  :  10.1186/s12877-022-02765-6

来源: Springer

【 摘 要 】

BackgroundSarcopenia is described as age-related progressive skeletal muscle failure that results in marked reduction in the patient’s independence and life quality. In this study, we explored the association of TP53 exon 4 Arg72pro (rs1042522) and Intron 3 16-bp Del/Ins (rs17878362) polymorphisms and their haplotypes with sarcopenia, anthropometric, body composition and biochemical parameters.MethodsA total of 254 older individuals (65 sarcopenic and 189 healthy) were recruited in this research and genotyped by PCR–RFLP. Linear regression was applied to find the correlation between TP53 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 polymorphism and haplotypes and the risk of sarcopenia was investigated by logistic regression.ResultsArg/Pro genotype carriers was at a lower (ORadj = 0.175, 95% CI = 0.068 – 0.447; P < 0.001) risk of sarcopenia compared to the Arg/Arg group. In haplotypes analysis, Arg-Ins (ORadj: 0.484, 95% CI = 0.231 – 1.011, P = 0.043) and Pro-Ins (ORadj: 0.473, 95% CI = 0.210 – 1.068, P = 0.022) haplotypes showed decreased risk of developing sarcopenia. Moreover, in the case of codon 72 polymorphism, skeletal muscle mass, appendicular lean mass (ALM), skeletal muscle mass index (SMI), hand grip strength and Triglycerides, for Intron 3 16-bp Del/Ins polymorphism, albumin, calcium, cholesterol, and LDL were different, and for the haplotypes, skeletal muscle mass, SMI, ALM, HDL and triglycerides were significantly different between groups.ConclusionsWe suggested that the Arg/Pro genotype of the codon 72 polymorphism in exon 4 of TP53, and Arginine-Insertion and Proline-Insertion haplotypes might decrease the risk of sarcopenia in Iranian older adults.

【 授权许可】

CC BY