The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study

BMC Musculoskeletal Disorders

Mohammad Hossein Dabbaghmanesh¹  Nima Montazeri-Najababady¹  Nazanin Chatrabnous¹  Nasrin Nasimi²  Zahra Sohrabi² 

[1] Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;

关键词: Sarcopenia;    Obesity;    p53;    Polymorphism;    Body mass index;   

DOI  :  10.1186/s12891-021-04314-5

来源: Springer

【 摘 要 】

BackgroundAging and obesity are the two major global health concerns. Sarcopenia, an age-linked disease, wherein a progressive loss of muscle volume, muscle strength, and physical activity occurs. In this study we evaluated the association of TP53 rs1625895 polymorphism with the susceptibility to sarcopenic obesity in Iranian old-age subjects.MethodsTotal of 176 old individuals (45 sarcopenic and 131 healthy) were recruited in this research and genotyped by PCR–RFLP. BMI, Skeletal Muscle Mass Index, body composition, Handgrip Strength, Gait Speed (GS), and biochemical parameters were measured. Chi-square test was done for genotypes and alleles frequency. Linear regression was applied to find the correlation between TP53 rs1625895 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 rs1625895 and the risk of sarcopenia and sarcopenic obesity was investigated by logistic regression.ResultsG allele was significantly higher in sarcopenic obesity group [P = 0.037, OR (CI 95%) = 1.9 (1.03–3.5)] compared to A allele. BMI (P = 0.049) and LDL (P = 0.04) were significantly differed between genotypes when GG was compared to AA/AG genotype. The results revealed when GG genotype compared to AA/AG genotype in adjusted model for age, the risk of sarcopenic obesity [P value = 0.011, OR (CI 95%); 2.72 (1.25–5.91)] increased. Similarly, GG/AG genotype increased the risk of sarcopenic obesity [P value = 0.028, OR (CI 95%); 2.43 (1.10–5.36)] in adjusted model for age compared to AA genotype.ConclusionsWe suggested that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population.

【 授权许可】

CC BY