The crewed journey to Mars and its implications for the human microbiome

Microbiome

Carmel Abbott¹  David A. Pearce¹  Alexander Mahnert²  Torben Kuehnast²  Manuela R. Pausan²  Christine Moissl-Eichinger³ 

[1] Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University at Newcastle, Northumberland Road, NE1 8ST, Newcastle-upon-Tyne, UK;Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010, Graz, Austria;Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Neue Stiftingtalstraße 6, 8010, Graz, Austria;BioTechMed, Graz, Austria;

关键词: Space;    Spacecraft;    Space traveler;    Astronauts;    Healthy;    Perturbation;    Reconstitution;    Diversity;    Gut;    Planetary protection;   

DOI  :  10.1186/s40168-021-01222-7

来源: Springer

【 摘 要 】

A human spaceflight to Mars is scheduled for the next decade. In preparation for this unmatched endeavor, a plethora of challenges must be faced prior to the actual journey to Mars. Mission success will depend on the health of its crew and its working capacity. Hence, the journey to Mars will also depend on the microbiome and its far-reaching effects on individual crew health, the spaceship’s integrity, and food supply. As human beings rely on their microbiome, these microbes are essential and should be managed to ensure their beneficial effects outweigh potential risks. In this commentary, we focus on the current state of knowledge regarding a healthy (gut) microbiome of space travelers based on research from the International Space Station and simulation experiments on Earth. We further indicate essential knowledge gaps of microbial conditions during long-term space missions in isolated confined space habitats or outposts and give detailed recommendations for microbial monitoring during pre-flight, in-flight, and post-flight. Finally, the conclusion outlines open questions and aspects of space traveler’s health beyond the scope of this commentary.6S6sxo-24do3XhevzaE9L1Video Abstract

【 授权许可】

CC BY