Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion

Advanced Science

Zhong Wang¹  Youxin Zhou¹  Yulun Huang²  Adekunle Adesina³  L. Frank Huang⁴  Sebastian Brabetz⁵  Marcel Kool⁵  Stefan M. Pfister⁶  Wan‐Yee Teo⁷  Sophie Xiao⁸  Frank K. Braun⁹  Holly Lindsay⁹  Tsz‐Kwong Man⁹  Jack M. F. Su⁹  Murali Chintagumpala⁹  Sibo Zhao⁹  Huiyuan Zhang⁹  Patricia Baxter⁹  Laszlo Perlaky⁹  Jianhua Yang⁹  Mari Kogiso⁹  Yuchen Du^1,10  Xiao‐Nan Li^1,10  Lin Qi^1,11 

[1] Department of Neurosurgery and Brain and Nerve Research Laboratory, the First Affiliated Hospital, Soochow University, Suzhou, 215007, China;Department of Neurosurgery, Dushu Lake Hospital, Soochow University, Suzhou, 205124, China;Department of Neurosurgery and Brain and Nerve Research Laboratory, the First Affiliated Hospital, Soochow University, Suzhou, 215007, China;Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA;Department of Pathology, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA;Department of Systems Medicine and Bioegineering, Houston Methodist Hospital Research Institute and Cancer Center, Weill Cornell Medicine, Houston, TX, 77030, USA;Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children’s Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, United States, 45229, United States;Hopp Children's Cancer Center (KiTZ), Heidelberg, 69120, Germany;Division of Pediatric Neuro‐oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, 69120, Germany;Hopp Children's Cancer Center (KiTZ), Heidelberg, 69120, Germany;Division of Pediatric Neuro‐oncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, 69120, Germany;Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, 69120, Germany;Humphrey Oei Institute of Cancer Research, National Cancer Center Singapore, Singapore, 169610, Singapore;Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA;Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA;Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA;Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA;Texas Children's Cancer Center, Texas Children's Hospital, Baylor College of Medicine, Houston, TX, 77030, USA;Program of Precision Medicine PDOX Modeling of Pediatric Tumors, Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA;Department of Pharmacology, School of Medicine, Sun Yat‐Sen University, Shenzhen, 518107, China;

关键词: 4‐aminopyridine;    glioblastoma;    KCNA1;    miRNA;    patient derived orthotopic xenograft;   

DOI  :  10.1002/advs.202101923

来源: Wiley

【 授权许可】

CC BY